Fortworth, TX US
Currently seeking a talented and innovative Scientist II to join the Biotherapeutics TCRm discovery department located in Fort Worth, TX. You will be responsible for investigating the biochemical and biophysical properties of proteins, developing protocols for production and purification of stabilized pHLA complexes, and design and execution of experiments to characterize pHLA complex structure, function, and stability
Duties & Responsibilities:
Investigate and characterize the biochemical and biophysical properties of peptides and proteins.
Develop, optimize, and execute protocols for production and purification of pHLA complexes
Design and execute experiments to characterize pHLA complex structure, function, and stability
Design and execute assays to assess protein-protein interactions
Be familiar with advanced theory and current developments in the field of pHLA protein refolding technologies
Demonstrate independent thinking, e.G. By proposing and implementing new experimental designs and concepts that contribute to research goals and reflect expert knowledge;identify potential patentable inventions
Create a culture of excellence through continual process improvement, scientific curiosity, and empowerment;develop and maintain outside visibility
Prepare clear technical reports, publications, and oral presentations;independently communicate results in the form of reports and or presentations;present responsibly and defend own work at scientific meetings;deliver project updates to senior level management
Contribute to departmental administration;demonstrate fiscal responsibility with respect to cost of experiments, technology, external collaborations, and travel
Comply with applicable regulations, perform all work in a safe manner;maintain proper records in accordance with SOPs and policies.
Experience in protein purification, analysis, and characterization
Proficiency in laboratory techniques such as chromatography, ELISA, electrophoresis, and PCR
Familiarity with biological databases, software tools and computational approaches for protein analysis is a plus
Background knowledge of general biotherapeutics discovery processes, including lead generation, protein science, biophysical and biochemical characterization is preferred
Experience in use of Microsoft Office tools and GraphPad (Prism)
Excellent written and oral presentation skills
Ability to work within a collaborative team environment, present and defend results to project and technical teams.